Overview

A Study of ALG-010133 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

Status:
Recruiting
Trial end date:
2022-08-01
Target enrollment:
0
Participant gender:
All
Summary
A Randomized Study of ALG-010133 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Aligos Therapeutics
Criteria
Inclusion Criteria for Healthy Subjects:

1. Male and Female between 18 and 55 years old

2. Female subjects must have a negative serum pregnancy test at screening

3. Subjects must be nonsmokers for at least 3 months prior to randomization

4. BMI 18.0 to 32.0 kg/m^2

5. Subjects must have a 12-lead ECG that meets protocol criteria

Inclusion Criteria for CHB Subjects:

1. Male and Female between 18 and 70 years old

2. Female subjects must have a negative serum pregnancy test at screening

3. BMI 18.0 to 35.0 kg/m^2

4. HBeAg-negative chronic hepatitis B or HBeAg-positive chronic hepatitis B and are
currently receiving HBV NA treatment for ≥6 months prior to screening

5. Subjects must have a 12-lead ECG that meets protocol criteria

Exclusion Criteria for Healthy Subjects:

1. Subjects with any current or previous illness that, in the opinion of the
Investigator, might confound the results of the study or pose an additional risk in
administering study drug to the subject or that could prevent, limit, or confound the
protocol specified assessments or study results' interpretation

2. Subjects with a past history of cardiac arrhythmias, risk factors for Torsade de
Pointes syndrome (e.g., hypokalemia, family history of long QT Syndrome) or history or
clinical evidence at screening of significant or unstable cardiac disease etc.

3. Subjects with a history of clinically significant drug allergy

4. Subject with current or history of clinically significant (as determined by the
Investigator) skin disease requiring intermittent or chronic treatment

5. Excessive use of alcohol defined as regular consumption of ≥14 units/week for women
and ≥21 units/week for men

6. Unwilling to abstain from alcohol use for 48 hours prior to start of dosing through
end of study follow up

7. Subjects with Hepatitis A, B, C, D, E or HIV-1/HIV-2 infection or acute infections
such as SARS- CoV-2 infection

8. Subjects with renal dysfunction (e.g., estimated creatinine clearance <90 mL/min/1.73
m^2 at screening, calculated by the Chronic Kidney Disease Epidemiology Collaboration
[CKD-EPI] formula)

Exclusion Criteria for CHB Subjects:

1. Subjects with any current or previous illness that, in the opinion of the
Investigator, might confound the results of the study or pose an additional risk in
administering study drug to the subject or that could prevent, limit, or confound the
protocol specified assessments or study results' interpretation

2. Subjects with a past history of cardiac arrhythmias, risk factors for Torsade de
Pointes syndrome (e.g., hypokalemia, family history of long QT Syndrome) or history or
clinical evidence at screening of significant or unstable cardiac disease etc.

3. Subjects with a history of clinically significant drug allergy

4. Subject with current or history of clinically significant (as determined by the
Investigator) skin disease requiring intermittent or chronic treatment

5. Excessive use of alcohol defined as regular consumption of ≥14 units/week for women
and ≥21 units/week for men

6. Subjects with Hepatitis A, C, D, E or HIV-1/HIV-2 infection or acute infections such
as SARS- CoV-2 infection

7. Subjects with renal dysfunction (e.g., estimated creatinine clearance <90 mL/min/1.73
m^2 at screening, calculated by the Chronic Kidney Disease Epidemiology Collaboration
[CKD-EPI] formula)

8. Subject with any history or current evidence of hepatic decompensation such as:
variceal bleeding, spontaneous bacterial peritonitis, ascites, hepatic encephalopathy,
or active jaundice (within the last year)

9. Subjects must have absence of signs of hepatocellular carcinoma

10. Subjects with history or current liver cirrhosis

11. Subjects positive for anti-HBs anitbodies

12. Subjects with liver fibrosis that is classified as Metavir Score ≥F3