Overview

A Study in Healthy Men to Test Whether BI 474121 Can Reverse the Memory Problems Caused by Ketamine

Status:
Not yet recruiting
Trial end date:
2023-03-01
Target enrollment:
0
Participant gender:
Male
Summary
To investigate the effect of BI 474121 compared to placebo on ketamine-induced cognitive deficits to predict efficacy in patients with cognitive disorders.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Boehringer Ingelheim
Treatments:
Ketamine
Criteria
Inclusion Criteria:

- Healthy male subjects according to the assessment of the investigator, as based on a
complete medical history including a physical examination, vital signs (blood pressure
(BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), and clinical laboratory tests

- Age of 18 to 55 years (inclusive)

- Body mass index (BMI) of 18.5 to 32 kg/m2 (inclusive)

- Signed and dated written informed consent(s) prior to admission to the study, in
accordance with International Council for Harmonisation-Good Clinical Practice
(ICH-GCP) and local legislation prior to admission to the trial

- If men who are able to father a child, are willing to participate, they have to use an
adequate form of effective contraception for the duration of study participation and
for at least 30 days after treatment has ended

Exclusion Criteria:

- Any finding in the medical examination (including ECG) deviating from normal and
assessed as clinically relevant by the investigator

- Repeated measurement of systolic blood pressure outside the range of 90 to 140 mmHg,
diastolic blood pressure outside the range of 50 to 90 mmHg, or pulse rate outside the
range of 50 to 90 bpm evaluated as clinically significant by Investigators

- Any laboratory value outside the reference range that the investigator considers to be
of clinical relevance

- Any evidence of a concomitant disease assessed as clinically relevant by the
investigator

- Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic,
immunological or hormonal disorders

- Cholecystectomy or other surgery of the gastrointestinal tract that could interfere
with the pharmacokinetics of the trial medication (except appendectomy or simple
hernia repair)

- History of diseases of the central nervous system (including but not limited to any
kind of seizures or stroke), and other relevant neurological or psychiatric disorders

- History of relevant orthostatic hypotension, fainting spells, or blackouts Further
exclusion criteria apply.