Overview

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

Status:
RECRUITING
Trial end date:
2031-02-13
Target enrollment:
Participant gender:
Summary
This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype. Previous large clinical trials have established treatment plans that are likely to cure most children with FHWT, however some children still have their cancer come back (called relapse) and not all survive. Previous research has identified features of FHWT that are associated with higher or lower risks of relapse. The term "risk" refers to the chance of the cancer coming back after treatment. Using results of tumor histology tests, biology tests, and response to therapy may be able to improve treatment for children with FHWT.
Phase:
PHASE3
Details
Lead Sponsor:
Children's Oncology Group
Treatments:
Carboplatin
Cyclophosphamide
Dactinomycin
Doxorubicin
Etoposide
High-Energy Shock Waves
Irinotecan
Magnetic Resonance Spectroscopy
Nephrectomy
Observation
Phantoms, Imaging
Vincristine
Watchful Waiting
X-Rays