A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

To test the ability of GSK256073 to block niacin-induced flushing when GSK256073 and niacin are co-administered as single doses to HVTs.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Niacin; Niacinamide; Nicotinic Acids

Criteria

Inclusion Criteria:

• Adult males between 18 and 55 years of age, inclusive.

• Healthy subjects

• Body weight > 50 kg (110 pounds) and body mass index (BMI) between 19 and 31 where:

• Subjects with QTc < 450 msec at screening

Exclusion Criteria:

• History of significant cardiac arrhythmias

• Active peptic ulcer disease (PUD) and/or history of PUD

• History of gout and/or hyperuricemia

• History of Gilbert's syndrome

• History of recurrent indigestion, stomach upset or diarrhea

• History of other than rare (once yearly or less) flushing

• Recurrent skin rash or psoriasis

• History of kidney stones