A Study To Evaluate The Difference In iPad-Based Cognitive Video Game (Akili Interactive's Project: EVO) Performance In Amyloid-Positive Versus Amyloid-Negative Healthy Elderly Volunteers

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the difference in learning and performance measures associated with repeated use of an iPad video game (Akili Interactive's Project: EVO) in healthy elderly volunteers based on amyloid status.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pfizer
• Treatments: Methylphenidate

Criteria

Inclusion Criteria:

• Healthy males and females between the ages of 70 and 80.

• Subjects must have BMI of 17.5 to 32 kg/m2 and total body weight > 110 pounds.

• Acceptable screening MRI and PET scans that pass quality control requirements.

Exclusion Criteria:

• Co-morbid diagnosis of clinically documented Alzheimer's disease; - Significant cognitive impairment;

• MMSE (mini mental state examination) score <26