Overview

A Study Evaluating the Safety and Efficacy of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
0
Participant gender:
All
Summary
This is a Phase 2, randomized, placebo controlled, multi-center study in subjects with mild to moderate IPF. Eligible subjects will be randomized to receive placebo or ENV-101 as a daily oral dose for 12 consecutive weeks of treatment. Following treatment, subjects will be observed for an additional 6 weeks.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Endeavor Biomedicines, Inc.
Criteria
Inclusion Criteria:

- IPF diagnosis based upon American Thoracic Association, Japanese Respiratory Society,
European Respiratory Society, Latin American Thoracic Association guidelines within
the last 7 years. Diagnosis will be confirmed to be consistent with IPF by centrally
read high resolution computed tomography (HRCT).

- Ability to successfully perform lung function tests.

- Subjects are willing to remain on study treatment for the duration of the study.

- Subjects have a full understanding of the informed consent.

Exclusion Criteria:

- Evidence of other known causes of interstitial lung disease (ILD) (e.g., domestic, and
occupational environmental exposures, connective tissue disease [CTD], and drug
toxicity), lung transplant expected within 12 months of screening or evidence of
clinically significant lung disease other than IPF including but not limited to
asthma, chronic obstructive pulmonary disease (COPD), uncontrolled pulmonary
hypertension and emphysema where computed tomography (CT)-assessed extent of emphysema
is greater than extent of fibrosis.

- History of malignancy, including carcinoma during the preceding 5 years. With the
following exceptions:

1. Prior history of in situ basal or squamous cell skin cancer if completely
excised.

2. Subjects with other malignancies if they have been continuously disease free for
at least 5 years prior to study start.

3. Subjects with prostate cancer that are managed by surveillance are also eligible.

- Current use of supplemental oxygen for any condition.

- Smoking within 6 months of study start, current smoker, or unwillingness to refrain
from smoking during the clinical trial duration.

- Presence of active infection at study start or confirmed active human immunodeficiency
virus (HIV), Hepatitis B virus (HBV), COVID-19 or Hepatitis C virus (HCV).

- Occurrence of serious illness requiring hospitalization within 90 days prior to study
start.

- Use of nintedanib or pirfenidone for greater than 60 days. Subjects must not have
taken nintedanib or pirfenidone for 14 days prior to study start.

- Current or previous use (within 30 days prior to study start) of the following:

1. N-acetylcysteine

2. endothelin receptor antagonist

3. riociguat

4. prostacyclin or prostacyclin analogue

5. Warfarin for IPF

6. Cytotoxic agents (e.g., colchicine if used for IPF)

7. Radiation to the lungs

8. Pulmonary rehabilitation

9. Investigational agent for IPF

10. Immunosuppressive medications such as methotrexate, azathioprine, systemic or
inhaled glucocorticosteroids used as a treatment for IPF.

- Regular use of phosphodiesterase type-5 inhibitor, occasional use for erectile
dysfunction will be allowed.

- Use of drugs that are known strong CYP3A4/5 inhibitors, inducers, or substrates within
12 days prior to study start.

- Males and females of reproductive potential who are sexually active and unwilling to
use birth control for the duration of the study and 30 days after their final dose.

- Females that are pregnant or lactating.

- Females and males that are unwilling to refrain from blood or blood product donation
for the duration of the study or for 30 days after their final study dose.

- Males who are unwilling to refrain from sperm donation for the duration of the study
or for 30 days after their final study dose.

- Subjects with a history of a severe allergic reaction or anaphylactic reaction or
known hypersensitivity to any component of ENV-101.

- Subjects who are immediate family members (spouse, parent, child, or sibling;
biological or legally adopted) of personnel directly affiliated with the study
investigative site or the study Sponsor.