A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED
Status:
Withdrawn
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
This is a prospective randomized, clinical trial comparing recurrent use of Morphine Sulfate
Immediate Release (MSIR), Oxycodone/Acetaminophen (Percocet), and Hydrocodone/Acetaminophen
(Vicodin) at discharge from the emergency department for opioid-naive adult patients
presenting with moderate-to-severe pain. At discharge, patients will be randomized to receive
either 5 mg of Oxycodone/Acetaminophen (Percocet) tablet 4 times a day for 5 days, 5 mg of
Hydrocodone/Acetaminophen (Vicodin) tablet 4 times a day for 5 days, or 15 mg Morphine
Sulfate Immediate Release (MSIR) tablet 4 times a day for 5 days. At 1 month, 3 months, and 6
months patients' prescription's history will be accessed by using the DoctorFirst Drug
Database to determine the recurrent use that will serve as a surrogate marker of likeability
and abuse liability of each prescribed opioid.
Phase:
Phase 4
Details
Lead Sponsor:
Antonios Likourezos
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Hydrocodone Morphine Oxycodone