A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
Status:
Recruiting
Trial end date:
2026-06-30
Target enrollment:
Participant gender:
Summary
Among patients with stable ischemic heart disease who are referred for coronary angiography,
a substantial proportion have non-obstructive coronary artery disease (CAD). Ischemia based
on symptoms or stress testing may be due to coronary microvascular dysfunction in up to 40%
of these patients. However, the mechanisms and optimal treatment of coronary microvascular
dysfunction are unknown. Aberrant platelet activity and inflammation have been hypothesized
as mechanisms of microvascular dysfunction. Investigators plan to evaluate association
between platelet activity, inflammation, and coronary microvascular dysfunction in stable
women referred for coronary angiography, and to identify non-invasive correlates of coronary
microvascular dysfunction in these patients.