A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Selective cyclooxygenase (COX)-2 inhibitors are commonly used analgesics that provide similar analgesia but reduced adverse effects compared to other analgesics. However, few studies have been conducted on postoperative pain and tendon-to-bone healing. Here, the investigators investigated the effect of a selective COX-2 inhibitor on analgesia and tendon-to-bone healing following arthroscopic rotator cuff repair.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Bundang Hospital
• Treatments: Celecoxib; Cyclooxygenase 2 Inhibitors; Ibuprofen; Tramadol

Criteria

Inclusion Criteria:

• Patients scheduled to undergo arthroscopic acromioplasty and rotator cuff repair for a partial or full thickness tear

• Age < 80 years at time of diagnosis

• Patient willing and able to comply with the study prescriptions

• Patient able to give written informed consent before patient registration/randomisation

Exclusion Criteria:

• Patients with rotator cuff tear arthropathy

• Severe osteoarthritis (Samilson-Prieto grade II or higher)

• Rheumatoid arthritis

• Chronic renal failure (i.e., at high risk for the use of NSAIDs or opioid drugs)

• Liver failure

• Myocardial infarction or chronic heart failure

• Cerebral vascular disease

• Active gastric ulcer or bleeding

• Allergies to NSAIDs or opioid drugs

• Previous surgery on the same side

• Pregnant or breast feeding patients

• Those not willing to participate in the trial