A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

• Status: Terminated
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate pain relief, safety, and tolerability of a new treatment (JNJ-42160443) for moderate to severe pain of osteoarthritis of the knee in comparison to a standard pain treatment and placebo.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
• Treatments: Analgesics; Oxycodone

Criteria

Inclusion Criteria:

• Clinical diagnosis of osteoarthritis of the knee

• Have moderate to severe pain based on a trial questionnaire

• Must be on a stable dose of pain medication for 4 weeks before entering the trial

• Medically stable condition

Exclusion Criteria:

• History of joint replacement surgery in the affected joint or planned surgery involving the affected joint during the trial

• Diabetes mellitus

• Uncontrolled cardiovascular disease or hypertension

• Previous treatment with another investigational NGF inhibitor therapy