A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)
Status:
Not yet recruiting
Trial end date:
2024-12-25
Target enrollment:
Participant gender:
Summary
This study will look at how much weight participants will lose from the start to the end of
the study. The weight loss in participants taking the investigational high dose of
semaglutide will be compared to the weight loss in people taking "dummy" medicine and a lower
dose of semaglutide. In addition to taking the medicine, participants will have talks with
study staff about healthy food choices and how to be more physically active. Participants
will either get semaglutide or "dummy" medicine. Which treatment participants get is decided
by chance. Participants are more likely (4 out of 5) to get semaglutide than the "dummy"
medicine. The study medicine will be injected briefly, under skin, with a thin needle,
typically in the stomach, thighs, or upper arms. In the first part of the study, participants
will get one injection once a week until they reach the planned dose. The second part of the
study, which might last a couple of months, is a transition period, where participant will
get three injections, taken right after each other, once a week. The duration of the study
intervention (trial product and lifestyle intervention) will be 72 weeks followed by a 9-week
follow-up period without study interventions.