A Relation of Morphine-induced Itch and Pain Processing

• Status: Completed
• Trial end date: 2020-07-07
• Target enrollment: 0
• Participant gender: All

Summary

In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch:

1. Opioids cause itch by a spinal disinhibition mechanism (central nervous system (CNS) effect).

2. Opioids cause itch through a mast cell-destabilizing effect leading to release of histamine and tryptase in the skin where itch is evoked (peripheral mechanism).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aalborg University
• Treatments: Codeine; Histamine; Histamine phosphate; Morphine

Criteria

Inclusion Criteria:

• Healthy men and women in the age of 20-65 years

• The participants must be able to speak and understand English

Exclusion Criteria:

• Participants with any clinically significant abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results.

• Pregnant or lactating female persons

• Drug addiction defined as the use of cannabis, opioids or other drugs

• Previous or present neurologic, musculoskeletal or mental illnesses

• Current pain and itch causing diseases or psychiatric disorders

• Participants unable to understand or follow the instructions

• Participating in another study where investigational drug is used

• Participants had known allergy/discomfort to morphine

• Lack of ability to cooperate