A Relation of Morphine-induced Itch and Pain Processing
Status:
Completed
Trial end date:
2020-07-07
Target enrollment:
Participant gender:
Summary
In This experiment, the investigators would like to test the two following hypotheses
regarding the mechanisms by which opioids cause itch:
1. Opioids cause itch by a spinal disinhibition mechanism (central nervous system (CNS)
effect).
2. Opioids cause itch through a mast cell-destabilizing effect leading to release of
histamine and tryptase in the skin where itch is evoked (peripheral mechanism).