A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis
Status:
Completed
Trial end date:
2005-06-01
Target enrollment:
Participant gender:
Summary
This study will test the effectiveness of two different tuberculosis (TB) prevention
strategies, DOTS or DOTS-A. DOTS is the current prevention strategy for TB. DOTS-A is an
enhanced prevention strategy that will screen household members of individuals diagnosed with
active TB and will provide enhanced treatment as needed. The study will be conducted in 8
communities located in Rio de Janeiro. Study participants will include 6400 males and females
of all ages, including active TB patients and their household contacts. Patients with TB
identified for treatment at the Health Clinics of 8 urban communities will be eligible. The
communities will be assigned to 1 of the 2 prevention strategies, DOTS or DOTS-A. After 4
years, the information gathered during the study will be used to determine the incidence of
TB in these communities to see which prevention strategy was more effective in decreasing TB.
Phase:
Phase 3
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)