A Randomized Prospective Trial Comparing Low-volume Bowel Preparation Methods
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
Colonoscopy is a common screening method to detect polyps and CRC. With the early detection
of CRC through screening colonoscopy, patients could have better therapeutic effects and
outcomes. In population screening programs, an increase in completed colonoscopies is related
to a decrease in mortality from CRC. However, the miss rate for detecting colorectal
neoplastic polyps of colonoscopy is 5-28%. The reluctance of participants to undergo bowel
preparation results in the relatively low rate of detection of polyps and CRC, because poor
preparation interferes with successful colon mucosa examination during a colonoscopy.
Low-volume bowel preparations provide equivalent cleansing effect compared with standard 4
liter polyethylene glycol. However, studies comparing the superiority between low-volume
bowel preparations are rare, and results are controversial. This study aimed to compare the
bowel cleansing quality and tolerability between split-dose sodium picosulfate/magnesium
citrate and polyethylene glycol with ascorbic acid.