A Randomized, Open-label, LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With Marfan Syndrome

• Status: Unknown status
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To assess the efficacy of angiotensin II receptor blocker, Losartan, to prevent progressive dilation of aortic root in patients with Marfan syndrome.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Atenolol; Losartan; Propranolol

Criteria

Inclusion criteria

• Marfan syndrome with recognized aortic root dilation

• Patients must be older than one year of age

• Beta-blocker treatment at least three months

• Must sign an informed consent form

Exclusion criteria

• Prior to aortic root surgery

• Aortic root dimension more than 5.5cm

• Aortic surgery within 6 months

• Diabetes mellitus or liver and renal dysfunction or asthma

• Pregnancy

• Intolerance to Losartan therapy