A Randomized, Open-label, Blinded Endpoint Assessment Study of Early PCSK9 Inhibitor Administration After Thrombectomy in Patients With Atherosclerotic Acute Ischemic Stroke.

• Status: RECRUITING
• Trial end date: 2026-08-30

Summary

This study (EPOCH-TECT) was a single-center, randomized, open-label, blinded, endpoint-assessing controlled trial conducted at the Affiliated Hospital of Xuzhou Medical University. It aimed to investigate the efficacy and safety of administering the PCSK9 inhibitor evolocumab early (within 6 hours) after successful thrombectomy in patients with atherosclerotic large vessel occlusive stroke. The study planned to enroll 60 patients, who were randomly assigned 1:1 to either the "thrombectomy + evolocumab" group or the "thrombectomy alone" group. The primary endpoint was the incidence of early neurological deterioration within 7 days post-procedure (NIHSS score increase 2 points from post-operative best or death from any cause); secondary endpoints included 24-hour recanalization failure rate, 90-day functional recovery (mRS score 0-2), changes in serum biomarkers, and safety indicators such as symptomatic intracranial hemorrhage. This study aimed to provide prospective evidence for early intensive lipid-lowering and neuroprotective strategies after thrombectomy.

• Phase: PHASE4

Details

• Lead Sponsor: The Affiliated Hospital of Xuzhou Medical University
• Treatments: Injections