Overview

A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours. Anyone diagnosed with a minor stroke faces the possibility of long-term disability and even death, regardless of treatment. Stroke symptoms such as weakness, difficulty speaking and paralysis may improve or worsen over the hours or days immediately following a stroke. TEMPO-2 is a minor stroke trial for patients presenting within 12 hours of their symptom onset. Patients will be randomized to TNK-tPA or standard of care. In the intervention group TNK-tPA is given as a single, intravenous bolus (0.25mg/Kg) immediately upon randomization. Maximum dose 50mg. The control group will receive antiplatelet agent(s) as decided by the treating physician. Antiplatelet agent(s) choice will be at the treating physician's discretion. TEMPO-2 Coordinating Centre is located in Calgary, AB, Canada. There will be approximately 50 sites participating worldwide. Dr. Shelagh Coutts is the Principal Investigator.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Calgary
Treatments:
Clopidogrel
Platelet Aggregation Inhibitors
Tenecteplase
Tissue Plasminogen Activator
Criteria
Inclusion Criteria:

1. Acute ischemic stroke in an adult patient (18 years of age or older)

2. Onset (last-seen-well) time to treatment time ≤ 12 hours.

3. TIA or minor stroke defined as a baseline NIHSS ≤ 5 at the time of randomization.
Patients do not have to have persistent demonstrable neurological deficit on physical
neurological examination.

4. Any acute intracranial occlusion or near occlusion (TICI 0 or 1) (MCA, ACA, PCA, VB
territories) defined by non-invasive acute imaging (CT angiography or MR angiography)
that is neurologically relevant to the presenting symptoms and signs. Multiphase CTA
or CT perfusion are required for this study. An acute occlusion is defined as TICI 0
or TICI 1 flow.1 Practically this can include a small amount of forward flow in the
presence of a near occlusion AND, Delayed washout of contrast with pial vessels on
multiphase CTA in a region of brain concordant with clinical symptoms and signs OR,
Any area of focal perfusion abnormality identified using CT or MR perfusion - e.g.
transit delay (TTP, MTT or T Max), in a region of brain concordant with clinical
symptoms and signs.

5. Pre-stroke independent functional status - structured mRS ≤2.

6. Informed consent from the patient or surrogate.

7. Patients can be treated within 90 minutes of the first slice of CT or MRI. Scans can
be repeated to meet this requirement; if there is no change neurologically then only a
CT head need be repeated for assessment of extent and depth of ischemia.

Exclusion Criteria:

1. Hyperdensity on NCCT consistent with intracranial hemorrhage.

2. Large acute stroke ASPECTS < 7 visible on baseline CT scan.

3. Core of established infarction. No large area (estimated > 10 cc) of grey matter
hypodensity at a similar density to white matter or in the judgment of the enrolling
neurologist is consistent with a subacute ischemic stroke > 12 hours of age.

4. Clinical history, past imaging or clinical judgment suggest that that intracranial
occlusion is chronic.

5. Patient has a severe or fatal or disabling illness that will prevent improvement or
follow-up or such that the treatment would not likely benefit the patient.

6. Pregnancy

7. Planned thrombolysis with IV tPA or endovascular thrombolysis/thrombectomy treatment.

8. In-hospital stroke unless these patients are at their baseline prior to their stroke.
E.g. a patient who had a stroke during a diagnostic coronary angiogram.

9. Commonly accepted exclusions for medical thrombolytic treatment. These are commonly
relative contraindications (i.e. the final decision is at the discretion of the
treating physician) but for the purposes of TEMPO-2 include the following:

- International normalized ratio > 1.7 or known full anticoagulation with use of
any standard or direct oral anticoagulant therapy with full anticoagulant dosing.
[DVT prophylaxis dosing shall not prohibit enrolment]. For low molecular weight
heparins (LMWH) more than 48 hours off drug will be considered sufficient to
allow trial enrollment. For direct oral anticoagulants; in patients with normal
renal function more than 48 hours off drug will be considered sufficient to allow
trial enrollment. Patients on direct oral anticoagulants who have any degree of
renal impairment should not be enrolled in the trial unless they have not taken a
dose of the drug in the last 5 days. Dual antiplatelet therapy does not prohibit
enrolment.

- Dual antiplatelet therapy does not prohibit enrolment. [For patients who are
known not to be taking anticoagulant therapy it is not necessary to wait for
coagulation lab results (e.g. PT, PTT) prior to treatment]

- Patients who have been acutely treated with GP2b3a inhibitors.

- Arterial puncture at a non-compressible site in the previous seven days

- Clinical stroke or serious head or spinal trauma in the preceding three months
that would normally preclude use of a thrombolytic agent.

- History of intracranial hemorrhage, subarachnoid hemorrhage or other brain
hemorrhage that would normally preclude use of a thrombolytic agent.

- Major surgery within the last 3 months at a bodily site where bleeding could
result in serious harm or death.

- Known platelet count below 100,000 per cubic millimeter. Treatment should not be
delayed to wait for platelet count unless thrombocytopenia is known or suspected.

- Gastrointestinal or genitourinary bleeding within the past 3 months that is
unresolved or associated with persisting anemia such that thrombolytic treatment
of any kind would result in serious bleeding or death.