A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands

• Status: Terminated
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to assess the effectiveness of intermittent preventive treatment in pregnancy (IPTp) with Sulphadoxine-pyrimethamine compared to chloroquine prophylaxis in Honiara, Solomon Islands for prevention of malaria and it's adverse effects in pregnancy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ministry of Health and Medical Services, Solomon Islands
• Collaborator: World Health Organization
• Treatments: Chloroquine; Chloroquine diphosphate; Fanasil, pyrimethamine drug combination; Pyrimethamine; Sulfadoxine

Criteria

Inclusion Criteria:

• Pregnant women aged 15 to 49 years

• Attending ANC clinic for the first time in this pregnancy

• Assigned routine ANC at a HCC health clinic

• Has experienced quickening (feeling the movements of the fetus)

• Gestation of 16 weeks to 32 weeks (as assessed by the last menstrual period [LMP] or by palpation if LMP is not available)

• Willing to adhere to all requirements of study

• Willing to provide informed written consent

• Planning to stay in Honiara for antenatal care and delivery

Exclusion Criteria:

• Used chloroquine prophylaxis in the current pregnancy before this ANC visit

• A history of allergic reaction to sulfa drugs (SP or cotrimoxazole

• Haemoglobin of < 7 g/dl

• Using folic acid in a dose of 5 mg daily (a dose of 1 mg daily or less is acceptable)

• Not willing to adhere to study requirements

• Women who are severely ill