A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Assisted reproductive technology (ART), especially controlled ovarian stimulation (COS),
significantly increased clinical pregnancy rates among infertile patients. However, about 9%
to 24% of patients had poor ovarian response to gonadotropins (GNS) stimulation, which was
called poor ovarian response (POR). In recent years, the diagnosis and treatment of patients
with low fertility is the challenge for reproductive medicine. To better demonstrate the
effectiveness of various interventions and distinguish the different subgroups of patients,
2016 POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number)
standard changed low reaction into low prognosis of patient-oriented individual strategies to
obtain eggs. For patients in group 3 and group 4 classified by POSEIDON, ovarian reserve
function decline, follicular development desynchrony and low numbers of oocytes obtained lead
to poor prognosis. In 2020, the prognosis based on Delphi method of assisted reproductive
technology to treat low crowd diagnosis expert opinion in China recommended to give these
patients conventional cosine solutions such as antagonist. In the first cycle, follicle
stimulating hormone (FSH) starting dose of 225 ~ 300 iu is suggested to achieve plenty of
ovarian stimulation for standards and maximize the benefits of superovulation. Because of the
particularity of luteal support in the antagonist regimen, it is of great clinical
significance to explore the trigger mode and combination mode of luteal support in the
antagonist regimen for patients with poor prognosis.