A Randomized Controlled Prophylactic Study of Clofazimine To Prevent Mycobacterium Avium Complex Infection in HIV Disease
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This study will examine the effectiveness of clofazimine in the prophylaxis of Mycobacterium
avium complex infection in HIV infected individuals who are at risk to develop this
untreatable opportunistic disease. In the absence of truly effective antiretroviral therapy,
a potential mode of treatment of patients with HIV infection is to prevent the development of
the life-threatening opportunistic infections. Current studies demonstrate a possible
efficacy of clofazimine in the prophylaxis against Pneumocystis carinii pneumonia (PCP), the
most common AIDS-defining opportunistic infection. Future studies will examine the potential
for prophylaxis against the other opportunistic infections. This proposal hopes to define the
role of prophylactic clofazimine in preventing the currently untreatable Mycobacterium avium
complex infection. AMENDED: To include prophylaxis for Asymptomatic and ARC.