A Randomized Clinical Trial of Megestrol Acetate as an Appetite Stimulant in Malnourished Children With Cancer
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to determine if megestrol acetate can be used as an
appetite stimulant to improve weight gain in children with cancer and poor nutrition. The
study design is a randomized, double blind, placebo controlled trial. Secondarily, we would
like to determine what effect any improvement in weight has on body composition by DEXA scan.
This includes whether the drug results in an increase in fat, fat-free mass, or both. If our
patients gain weight we would like to know if it improves their quality of life. Finally,
many children with cancer lose too much weight and require feeding to occur through a tube
put down their nose into their stomach (NG feeding). The tube can be painful to put down and
is uncomfortable when in. Some children may also require nutrition to be given into a vein
(Total Parenteral Nutrition or TPN). We are trying to see if we can prevent these procedures
from happening by having the subjects gain weight. This study will tell doctors if the drug
truly works (or does not work) in children who are underweight.
Phase:
N/A
Details
Lead Sponsor:
University of British Columbia
Collaborator:
University of Alberta
Treatments:
Appetite Stimulants Central Nervous System Stimulants Megestrol Megestrol Acetate