A Randomized Clinical Trail of The Effect of Postoperative Uric Acid Control on Stone Recurrence and Renal Function in Patients With Hyperuricemia of Urolithiasis.

• Status: Enrolling by invitation
• Trial end date: 2022-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to explore the effects of uric acid control on stone recurrence and renal function in patients with calculi of hyperuricemia through a prospective controlled study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xuhui Central Hospital, Shanghai
• Treatments: Febuxostat

Criteria

Inclusion Criteria:

• .Over 18 years old, under 70 years old, regardless of sex .The subjects had no mental illness or language dysfunction, could understand the situation of this study and had signed an informed consent form.

.No clinical manifestations of urinary tract infection, urinary routine examination showed urinary tract infection, but urinary etiology test was negative (urinary routine leukocytosis), treated with broad-spectrum antibiotics for more than 3 days.

.Clinical manifestations of urinary tract infection, urine routine examination showed urinary tract infection, and patients with positive urinary etiology were treated with sensitive antibiotics for more than 7 days.

• Serum uric acid value ≥480 µmol / L

• urinary stones

Exclusion Criteria:

• Transplanted kidney

• Fever or urinary tract infection is not treated according to the inclusion criteria

• Pregnant women and female menstruation

• Unable to tolerate anesthesia or surgery due to severe systemic disease, heart disease, pulmonary insufficiency and important organ failure

• Patients with renal insufficiency Clcr <30 mL/min

• Those who take side effects of febuxostat，Patients with side effects of febuxostat, patients with a previous history of coronary heart disease