A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in Adult
Status:
Suspended
Trial end date:
2006-12-01
Target enrollment:
Participant gender:
Summary
Sepsis sometimes occurs in people who have a serious infection. It is caused by toxic
substances (toxins) from bacteria and other germs entering your bloodstream. Most people with
sepsis will recover with routine medical care before the illness gets more serious. However,
in some people, sepsis does become more serious. This severe sepsis can cause damage to
internal organs (such as your heart, lungs, kidneys, and liver) and can be life threatening.
Special natural fats, (called 'lipoproteins') in our blood are thought to help protect us
from the toxins produced by bacteria during sepsis. Levels of these lipoproteins are often
low in people with sepsis and this may make it more difficult to recover from the disease.
GR270773 is a new drug that has been developed to help the lipoproteins in protecting the
body against toxins. GR270773 is made from purified fats and oils from the soyabean and does
not contain cholesterol. This research study will test the safety (side effects) of GR270773
and whether or not it is effective in preventing complications in people with severe sepsis.