A RCT of the Efficacy of Vonoprazan 20mg QD in the Treatment of Helicobacter Pylori Infection
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The treatment of helicobacter pylori is very important. The routine treatment is quadruple
therapy. In recent years, double therapy has appeared and the curative effect is fair.
However, antacid generally uses proton pump inhibitor. The proton pump inhibitor needs double
dose to achieve good antacid curative effect. The effect of vonoprazan used for inhibiting
gastric acid is better than proton pump inhibitor. At present, many studies use vonoprazan
instead of common proton pump inhibitor, but almost all use double dose of vonoprazan. In the
previous study, we found that the effect of double dose of proton pump inhibitor can be
achieved with 20mg QD of vonoprazan. Therefore, in this study, 20mg QD of vonoprazan was used
to replace the double dose of proton pump inhibitor to observe the antibacterial effect of
vonoprazan on Helicobacter pylori.