A RCT of Ondansetron and Promethazine in the Treatment of Nausea and Vomiting in the Emergency Department

• Status: Completed
• Trial end date: 2005-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This was a trial comparing two commonly used medications for nausea and vomiting, ondansetron and promethazine, in the Emergency Department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of New Mexico
• Collaborator: GlaxoSmithKline
• Treatments: Diphenhydramine; Ondansetron; Promethazine

Criteria

Inclusion Criteria:

• Age 18 or older

• Chief complaint of nausea or vomiting

Exclusion Criteria:

• Age less than 18

• unable to provide informed consent

• rate nausea at < 40 mm on 100 mm VAS

• received antiemetic within 24 hours

• pregnant or possibly pregnant

• reported allergy to either study medication

• received more than 1 liter of intravenous fluids

• their primary ED physician declined to have patient participate