A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)

• Status: Withdrawn
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Diuretics; Furosemide; Metolazone; Spironolactone

Criteria

Inclusion Criteria:

1. dyspnea at rest or minimal activity

2. tachypnea (respiratory rate > 20/min) or rales or pulmonary edema on chest X-ray

3. who need diuretics add over 40mg of daily furosemide dose

Exclusion Criteria:

1. Hospitalization for acute heart failure decompensation

2. cardiogenic shock (Systolic Blood Pressure < 80mmHg)

3. Need or plan for renal replacement therapy (dialysis, kidney transplant)

4. serum creatine level > 2.5mg/dl

5. serum potassium (K+) > 5.5mg/dl

6. daily spironolactone dose > 50mg

7. previous thiazide or metolazone user

8. Age > 75 years old or poor compliance patients 9. allergy, adverse drug reaction, hypersensitivity to any kinds of diuretics 10. life expectancy < 6 months (e.g. metastatic malignancy, liver cirrhosis) 11. pregnancy or women at age of childbearing potential