A Prospective Controlled Treatment Trial for Post-Traumatic Headaches
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Post-traumatic headaches (PTH) are the most common complaint after traumatic brain injury,
possibly generated by a number of stressors to the trigeminovascular and cervical plexus
networks, including inflammation of the high cervical facet joints, traumatic cranial
neuralgias, migraines, and myofascial injuries. To date, no treatment guidelines exist for
PTH management except for conservative modalities, such as cognitive rest, physical therapy,
and neuropathic pain medications, all of which have minimal evidence to support them.
The investigators propose a randomized, controlled, clinical trial and prospective follow-up
study to evaluate the effect of invasive procedures such as occipital nerve block (ONB) and
cervical medial branch block (CMBB) in the management of PTH.
Adolescents and adults (14-45 years of age) will be recruited from Boston Children's Hospital
and Beth Israel Deaconess Medical Center Pain clinics, Concussion clinics and Headache
clinics.
Phase:
Phase 3
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital
Collaborators:
Beth Israel Deaconess Medical Center Harvard University