A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness

• Status: Completed
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness; Part 2: To explore if quantitative EEG reactivity might predict the prognosis of disorders of consciousness.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Xijing Hospital
• Collaborators: Guangzhou University of Chinese Medicine; Tianjin University; University of Melbourne
• Treatments: Zolpidem

Criteria

Inclusion Criteria:

• presence of unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS) on admission;

• time since onset > 4 weeks;

• no history of neurodegenerative or psychiatric diseases.

Exclusion Criteria:

• allergic to zolpidem;

• currently receiving zolpidem or related benzodiazepines;

• diagnosed with seizure or status epilepticus.