A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine whether xenon - as compared to sevoflurane - can be applied safely in patients for general anesthesia before and after CABG implantation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RWTH Aachen University
• Collaborator: German Research Foundation
• Treatments: Sevoflurane; Xenon

Criteria

Inclusion Criteria:

• Patients with coronary artery disease scheduled for elective CABG

• Patients willing and able to complete the requirements of this study

• Ejection Fraction > 50%

• EuroSCORE ≤ 8

• men and women >= 50 yrs

• women without childbearing potential

• ASA Score II-IV

Exclusion Criteria:

• Lack of informed consent

• EuroSCORE < 8

• MMSE < 24

• Age < 50 years

• COPD GOLD > II, increased need of oxygen

• Renal dysfunction

• Liver function disorders

• Acute coronary syndrome during the last 24 hours; hemodynamic instability

• Requirement of inotropic support

• Off-pump-surgery

• Disabling neuropsychiatric disorders

• History of stroke with residuals

• Hypersensitivity to the study anaesthetics

• Increased intracranial pressure

• Pregnancy and lactation period

• Women of childbearing potential

• Presumed uncooperativeness or legal incapacity

• Participation in a concomitant trial