A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Status:
Completed
Trial end date:
2019-11-01
Target enrollment:
Participant gender:
Summary
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems
Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic
clinical trial demonstration project that directly informs national trauma care system policy
targeting injured patients with presentations of Posttraumatic Stress Disorder (PTSD) and
related comorbidity. Each year in the United States (US), over 30 million individuals present
to trauma centers, emergency departments, and other acute care medical settings for the
treatment of physical injuries. Multiple chronic conditions including enduring PTSD, alcohol
and drug use problems, depression and associated suicidal ideation, pain and somatic symptom
amplification, and chronic medical conditions (e.g., hypertension, coronary artery disease,
diabetes, and pulmonary diseases) are endemic among physical trauma survivors with and
without traumatic brain injuries (TBI). Evidence-based, collaborative care/care management
treatment models for PTSD and related comorbidities exist. These care management models have
the potential to be flexibly implemented in order to prevent the development of chronic PTSD
and depressive symptoms, alcohol use problems, and enduring physical disability in survivors
of both TBI and non-TBI injuries; care management models may also be effective in mitigating
the impact of the acute injury event on symptom exacerbations in the large subpopulation of
injury survivors who already carry a substantial pre-injury burden of multiple chronic
medical conditions.
Phase:
N/A
Details
Lead Sponsor:
University of Washington
Collaborators:
National Institute of Mental Health (NIMH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health (NIH)