A Pilot Trial of Triheptanoin for the Preventive Treatment of Migraine

• Status: Unknown status
• Trial end date: 2016-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

A pilot trial of triheptanoin, a natural compound able to promote anaplerotic mitochondrial metabolism, for the preventative treatment of migraine.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital of Liege; University of Liege

Criteria

Inclusion Criteria:

• Females aged 18-65 years old having an effective contraception or being menopaused

• Diagnosis of migraine without aura (ICHD3beta 1.1) since at least 2 years

• 4-10 migraine days per month during the last 3 months

• No preventive anti-migraine therapy during the last month

Exclusion Criteria:

• > 4 tension-type headache episodes per month

• Medication overuse headache or other headache types

• Resistance to >3 previous preventive anti-migraine drug treatments

• Any serious medical or psychiatric condition

• On-going or previous bowel disorder