Overview

A Pilot Study to Determine the Relative Bioavailability of Mosapride 5mg From Two Candidate Formulations of GR107719B Relative to One 5mg Tablet of Reference Mosapride Citrate (GASMOTIN™) in Healthy Adult Human Subjects Under Fasting Conditions

Status:
Completed
Trial end date:
2014-03-18
Target enrollment:
0
Participant gender:
All
Summary
This study aims to determine the relative bioavailability of two candidate formulations of mosapride citrate 5mg tablets compared the reference product GASMOTIN (mosapride citrate 5mg) from Dainippon Pharmaceutical Company in healthy adult subjects. This will be an open-label, randomised, single dose, three-way crossover, six sequence study. Subjects will receive a single oral dose separated by at least 7 days and no greater than 14 days washout period. This study is required to select a candidate mosapride citrate (GR107719B) formulation for further development and provide data to allow the design of a future pivotal bioequivalence study. The candidate formulations will be compared with the innovator GASMOTIN. GASMOTIN is a trademark of Dainippon Sumitomo Pharmaceutical Company.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
GlaxoSmithKline
Treatments:
Citric Acid
Mosapride
Criteria
Inclusion Criteria:

- Male and females aged between 18 and 65 years of age inclusive, at the time of signing
the informed consent.

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and
cardiac monitoring. A subject with a clinical abnormality or laboratory parameter(s)
which is/are not specifically listed in the inclusion or exclusion criteria, outside
the reference range for the population being studied may be included only if the
Investigator in consultation with the GSK Medical Monitor if required agree and
document that the finding is unlikely to introduce additional risk factors and will
not interfere with the study procedures.

- Body weight >= 50 kilogram (kg) and body mass index within the range 19 - 24.9 kg/m^2
(inclusive).

- A female subject is eligible to participate if she is of: Non-childbearing potential
defined as pre-menopausal females with a documented tubal ligation or hysterectomy for
this definition, "documented" refers to the outcome of the investigator's/designee's
review of the subject's medical history for study eligibility, as obtained via a
verbal interview with the subject or from the subject's medical records; or
postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a
blood sample with simultaneous follicle stimulating hormone (FSH) > 40
milli-international units per milliliter (MlU/mL) and estradiol < 40 picograms per
mililiter (pg/mL) [<147 picomole per liter] is confirmatory]. Females on hormone
replacement therapy (HRT) and whose menopausal status is in doubt will be required to
use one of the contraception methods if they wish to continue their HRT during the
study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal
status prior to study enrollment. For most forms of HRT, at least 2-4 weeks will
elapse between the cessation of therapy and the blood draw; this interval depends on
the type and dosage of HRT. Following confirmation of their post-menopausal status,
they can resume use of HRT during the study without use of a contraceptive method;
Child-bearing potential with negative pregnancy test as determined by serum human
chorionic gonadotrophin (hCG) test at screening or prior to dosing AND; Agrees to use
one of the contraception methods listed in protocol for an appropriate period of time
(as determined by the product label or investigator) prior to the start of dosing to
sufficiently minimize the risk of pregnancy at that point. Female subjects must agree
to use contraception until the follow-up contact visit; OR has only same-sex partners,
when this is her preferred and usual lifestyle.

- Male subjects with female partners of child-bearing potential must agree to use one of
the contraception methods listed in Protocol. This criterion must be followed from the
time of the first dose of study medication until the follow-up contact visit.

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form

- Alanine aminotransferase, alkaline phosphatase and bilirubin <=1.5x upper limit of
normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated
and direct bilirubin <35%).

- Based on single or averaged corrected QT interval (QTc) values of triplicate
electrocardiograms obtained over a brief recording period: QTcF < 450 msec

Exclusion Criteria:

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

- History of regular alcohol consumption within 6 months of the study defined as: An
average weekly intake of >21 units for males or >14 units for females. One unit is
equivalent to 8 gram of alcohol: a half-pint (approximately 240 milliliter [mL]) of
beer, 1 glass (100 mL) of wine or 1 (25 mL) measure of spirits.

- History of sensitivity to heparin or heparin-induced thrombocytopenia.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- Gastrointestinal disease or with gastrointestinal surgical history which can affect
the absorption of the investigational product.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening

- Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or
nicotine-containing products within 6 months prior to screening.

- A positive pre-study drug/alcohol screen.

- A positive test for Human Immunodeficiency Virus (HIV) antibody.

- Pregnant females as determined by positive serum hCG test at screening or prior to
dosing.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 90 day period.

- Lactating females.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 90 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.