A Pilot Study on Edoxaban for the Resolution of Left Atrial Thrombosis in Patients With Non-valvular Atrial Fibrillation
Status:
Completed
Trial end date:
2021-04-30
Target enrollment:
Participant gender:
Summary
Isolated reports have indicated that complete Left Atrial or Left Atrial Appendage thrombus
resolution may be achieved also with use of oral Factor Xa inhibitors, which have
demonstrated the same efficacy but a better safety profile compared to warfarin.
The aim of this open-label pilot study is to investigate the percentage of Left Atrial /Left
Atrial Appendage thrombus resolution with edoxaban therapy in patients with non-valvular
atrial fibrillation. The subordinated aim is the design a larger and longer study to compare
edoxaban and warfarin in the same patient population.
With the exception of few case reports, there are no data in the same patient population
referred to antithrombotic treatments other than vitamin K antagonists.