A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to gather pilot data to determine feasibility of and guide the development of a larger clinical trial investigating the effects of topiramate as an adjunct to nicotine replacement therapy and behavioral counseling in smoking cessation treatment. It is hypothesized that topiramate will decrease nicotine craving and result in improved outcomes for smoking cessation.

• Phase: Phase 2

Details

• Lead Sponsor: Emory University
• Treatments: Nicotine; Topiramate

Criteria

Inclusion Criteria:

• Male, between ages of 18-55

• Meets DSM-IV criteria for nicotine dependence

• Smoke at least 20 cigarettes per day

• Motivated to quit smoking

Exclusion Criteria:

• Serious or unstable medical conditions

• Current psychiatric disorder requiring medication or treatment

• Taking medication that create risk of interaction with study drug

• Current participation in another smoking cessation treatment