A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
This is an open label, controlled study.
The investigators are studying if the FDA approved diabetes medicine liraglutide (Victoza®)
can improve sleep apnea in adults. This study is testing liraglutide in 20 adults without
diabetes that are diagnosed with sleep apnea.The treatment group will be compared to a
control group of 10 adults without diabetes who have sleep apnea but will not use
liraglutide. Both groups will continue receiving standard of care for their sleep apnea as
prescribed by their managing sleep physician throughout their study participation.
Everyone in the study will have two study visits and one overnight sleep study for research.
Subjects who have not had a recent sleep study but otherwise qualify for the study, will have
an additional research sleep study to determine the baseline severity of their sleep apnea.
The study visits include fasting blood samples and breathing tests (pulmonary function test
and hypercapnic challenge). There will be weekly phone visits that include a questionnaire on
sleepiness. The group that takes liraglutide will check their blood sugar two times a day
while on the medicine.