A Pilot Study of the Bioavailability of Nasal Naloxone
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
The overall is aim of this pilot study is to give a preliminary estimation of key parameters
of the pharmacokinetics of a proper formulation of intranasal naloxone. These data will be
used to design a well justified protocol for the final estimation of these parameters:
- Preliminary estimation of bioavailability of this intranasal naloxone in human, healthy
volunteers
- Preliminary estimation of the maximum serum concentration (Cmax) of this formulation
- Preliminary estimation of the time to maximum serum concentration (Tmax) of this
formulation
- Safety of the formulation