A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
This clinical trial is for men and women with high-grade gliomas. Glucose (sugar) is thought
to be a contributor to tumor growth. The ketogenic diet (a high fat, low carbohydrate diet)
and metformin (a drug approved by the Food and Drug Administration to treat type 2 diabetes)
are both known to lower blood glucose levels. The purpose of the study is to evaluate the
tolerability of a ketogenic diet in conjunction with metformin and whether maintaining and
the diet with metformin will have any effect on participants. Participants will prepare their
own meals with the help of a nutritionist. Participants will continue on treatment as long as
they are responding to therapy and not experiencing unacceptable side effects