A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4+ T Cells > 350 Cells/mm3

• Status: Terminated
• Trial end date: 2005-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To define the safety and efficacy of sibling-supplied, HIV antigen-pulsed dendritic cells in increasing the immune response in HIV-infected patients.

Dendritic cells are a type of white blood cell used by the body to fight infection. They are instrumental in presenting antigens (such as HIV antigens) to the body's immune system. Since dendritic cells are not functioning maximally in HIV-infected patients, infusion of dendritic cells from an HIV-negative sibling may enable the affected sibling's immune system to recognize foreign particles more readily and increase immune response against the virus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Vaccines

Criteria

Inclusion Criteria

Patients must have:

• HLA A2+.

• Same cell type as donor sibling.

• CD4 count > 350 cells/mm3.

• HIV asymptomatic status.

• No HIV antivirals during study.

• Normal labs and chest x-ray.

Donor siblings must have:

• HLA A2+.

• HIV negativity.

• Ability to donate cells on multiple occasions.

• Negative status for hepatitis B and C.

Exclusion Criteria

Concurrent Medication:

Excluded:

• Antiviral therapy (unless CD4 count declines to < 350 cells/mm3).

Prior Medication:

Excluded:

• Antiviral therapy within 90 days prior to study entry.