Overview

A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity

Status:
Terminated
Trial end date:
2007-05-01
Target enrollment:
0
Participant gender:
All
Summary
The purposes of this study are to find out whether dextromethorphan can prevent the short or long-term neurologic side effects of methotrexate, and whether dextromethorphan can improve symptoms of short-term neurologic side effects if they do occur.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Medicine and Dentistry of New Jersey
Treatments:
Dextromethorphan
Methotrexate
Criteria
Inclusion Criteria:

- Newly diagnosed acute lymphocytic leukemia (ALL), non-Hodgkin's lymphoma (NHL) or OS.
Patients will be separately stratified and randomized by disease.

- Patients with history of seizures are eligible but will be stratified separately.

Exclusion Criteria:

- Patients taking monoamine oxidase inhibitors (MAOIs) will be excluded from the study,
because of the risk of severe drug interactions.

- Pregnant or lactating women.