Overview

A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung

Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
0
Participant gender:
All
Summary
Because of the effect in the treatment of NSCLC, the capecitabine and erlotinib may compose to a new regimen for NSCLC. Based on the preclinical observation and the confirmed clinical synergistic anti-tumor activity of combined capecitabine and erlotinib in gemzar refractory advanced pancreatic cancer (APC), the investigators previously conducted a phase II study of erlotinib in combination with capecitabine against NSCLC.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sun Yat-sen University
Treatments:
Capecitabine
Erlotinib Hydrochloride
Criteria
Inclusion Criteria:

1. Histological or cytological documented stage IIIB (not amenable for radical
/loco-regional therapy) or stage IV (metastatic) adenocarcinoma of lung. Sputum
cytology alone is excluded.

2. Measurable disease, according to the Response Evaluation Criteria in Solid Tumours
(RECIST), the presence of at least one unidimensionally measurable lesion with longest
diameter ≥ 20 mm by conventional techniques OR 10 mm by spiral CT scan.

3. Age ≥ 65.

4. Life expectancy of at least 3 months.

5. Never previously treated with radiotherapy, chemotherapy or surgery for malignant
disease.

6. Neutrophil count ≥ 1.5 × 109/L or platelets ≥ 75× 109/L or hemoglobin ≥ 10g/dL

7. Adequate hepatic function including prothrombin time ≥70%of the reference, AST/ALT
≤2.5×institutional upper limit of normal (ULN) or ≤5×ULN if liver metastases, alkaline
phosphatase ≤5×ULN (or ≤20×ULN if liver metastases),total bilirubin ≤1.5×ULN

8. Male or female. Age ≥ 18 years.

9. Written (signed) informed consent.

10. Able to comply with study and follow-up procedures.

Exclusion Criteria:

1. Patients with prior surgery or thoracic radiotherapy.

2. Patients with prior chemotherapy or other systemic anti-tumour therapy (e.g.
monoclonal antibody therapy or EGFR-TKI) .

3. Lack of physical integrity of the upper gastrointestinal tract, or malabsorption
syndrome, or inability to take oral medication, or active peptic ulcer disease.

4. Any inflammatory changes of the surface of the eye.

5. Any diseases, metabolic dysfunction, physical examination finding, or clinical
laboratory finding giving reasonable suspicion of a disease or condition that
contraindicates the use of any study medication (Erlotinib,Capecitabine) or that might
affect the interpretation of the results or render the subject at high risk from
treatment complications.

6. Pregnant or lactating women.

7. Woman of childbearing potential with either a positive or no pregnancy test at
baseline. Postmenopausal women must have been amenorrhoeic for at least 12 months to
be considered of non-childbearing potential.

8. Sexually active males and females (of childbearing potential) unwilling to practice
contraception during the study.

9. Any unstable systemic disease (including active infection, uncontrolled hypertension,
unstable angina, congestive heart failure, myocardial infarction within the previous
year, serious cardiac arrhythmia requiring medication, hepatic, renal or metabolic
disease).

10. History of another malignancy within the last 5 years except cured basal cell
carcinoma of skin and cured carcinoma in-situ of uterine cervix.

11. Patient who are at risk (in the investigator's opinion) of transmitting human
immunodeficiency virus (HIV) through blood or other body fluids are excluded.

12. Patients who have brain metastasis or spinal cord compression that has not yet been
definitively treated with surgery and/or radiation will be excluded; previously
diagnosed and treated CNS metastases or spinal cord compression without evidence of
stable disease (clinically stable imaging) for at least 2 months will also be
excluded.

13. Hypersensitivity to Erlotinib or Capecitabine