A Phase II Study of Oxaliplatin Capecitabine and Pre-operative Radiotherapy for Patients With Locally Advanced and Inoperable Rectal Cancer

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To assess the efficacy and safety of pre-operative capecitabine and oxaliplatin followed by capecitabine with concurrent radiotherapy followed by post-operative capecitabine in the treatment of patients with locally advanced or inoperable rectal cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Royal Marsden NHS Foundation Trust
• Treatments: Capecitabine; Oxaliplatin

Criteria

Inclusion Criteria:

• Age over 18.

• Histological diagnosis of adenocarcinoma of rectum.

• Locally advanced/ poor prognosis primary rectal cancer defined by MRI criteria of any of the categories below;

• Tumour within 2 mm of mesorectal fascia ie circumferential resection margin threatened

• Any T3 tumour at/below levatores

• T3c tumour at any other level ie tumour extends >5 mm into peri-rectal fat

• T4 tumour

• Any T stage with 4 or more involved lymph nodes

• WHO performance status 0, 1 or 2.

• No evidence of metastatic disease as determined by CT scan of chest, abdomen, pelvis or other investigations such as PET scan or biopsy if required.

• Adequate bone marrow function with platelets > 100 X 109/l; WBC > 3 X 109/l; neutrophils > 1.5 X 109/l

• Normal renal function, with serum creatinine within the normal range or calculated creatinine clearance >50 ml/min.

• Adequate hepatic function with serum total bilirubin < 1.5 X upper limit of normal range.

• No concurrent uncontrolled medical conditions

• No previous malignant disease other than non-melanotic skin cancer or carcinoma in situ of the uterine cervix

• Adequate contraceptive precautions if relevant

• Informed written consent

Exclusion Criteria:

• Medical or psychiatric conditions that compromise the patient's ability to give informed consent

• Presence of metastatic disease or recurrent rectal tumour

• Renal impairment (creatinine clearance<30 ml/min)

• Pregnancy or breast feeding

• Patients with a lack of physical integrity of the upper gastrointestinal tract, or known malabsorption syndromes

• Participation in any investigational drug study within the previous 4 weeks.

• Clinically significant (i.e. active) cardiac disease (e.g. congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmia even if controlled with medication) or myocardial infarction within the last 12 months)

• Patients with any symptoms or history of peripheral neuropathy.

• Prior pelvic radiotherapy