A Phase I Study of MGCD0103 Given Three-Times Weekly In Patients With Leukemia Or Myelodysplastic Syndromes

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, MGCD0103, a new anticancer drug under investigation, is given three times weekly to patients with leukemia or myelodysplastic syndromes.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mirati Therapeutics Inc.
• Treatments: Mocetinostat

Criteria

Inclusion Criteria:

• Patients must have a diagnosis of one of the following:

• relapsed or refractory AML or ALL that has failed to respond to standard therapy, has progressed despite standard therapy

• relapsed or refractory Myelodysplastic Syndromes

• previously untreated AML or Myelodysplastic Syndromes in patients > 60 years of age who refused or are not candidates for induction chemotherapy

• Patients with relapsed or refractory CML that has failed to respond to Imatinib therapy or standard therapy, has progressed despite standard therapy, or for which no standard therapy exists

• ECOG performance status of 0, 1, or 2

• Age ≥ 18 years

• Patients or their legal representative must be able to read, understand, and sign a written informed consent (approved by the IRB/EC) prior to study entry

Exclusion Criteria:

• Patients with a history of another cancer other than basal cell carcinoma or cervical intraepithelial neoplasia

• Pregnant or lactating women

• Patients and their partners, if either are of childbearing potential, not using adequate birth control measures throughout the study and for 90 days following the last dose of study medication

• Patients with known meningeal metastasis(es)

• Patients with active or uncontrolled infections, or with a fever >38.5 C

• Patients with serious illnesses, medical conditions, or other medical history, which would be likely to interfere with a patient's participation in the study

• Patients who have been treated with any investigational drug or anti-cancer therapy within 30 days of study start.