Overview

A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects

Status:
Completed
Trial end date:
2016-11-01
Target enrollment:
0
Participant gender:
All
Summary
The current study is designed to assess the safety, tolerability, pharmacokinetics (PK), gastrointestinal (GI) transit time and pharmacodynamic (PD) biomarkers of repeat oral doses of GSK3179106 administered for 14 days in normal healthy subjects. It is a randomized, double-blind, placebo-controlled, ascending cohort study. A total of 48 subjects will be randomized (8 subjects/cohort) with 3:1 allocation to GSK3179106 or matching placebo.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
GlaxoSmithKline
Criteria
Inclusion Criteria:

- Between 18 and 55 years of age inclusive, at the time of signing the informed consent.

- Healthy as determined by the investigator based on a medical evaluation including
medical history, physical examination, laboratory tests and cardiac monitoring.
History of regular bowel habits

- Male or Female of non-childbearing potential.

- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions

Exclusion Criteria:

- ALT and bilirubin >1.5xupper limit of normal (ULN) (isolated bilirubin >1. ULN is
acceptable if bilirubin is fractionated and direct bilirubin <35%).

- Estimated Glomerular Filtration Rate <60 milliliter per minute per 1.73 square meter
(mL/min/1.73m^2)

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones)

- History of Gastroesophageal reflux disease (GERD), dyspepsia, GI bleeding, GI surgery
that could affect motility