A Phase 2 Safety and Efficacy Study of PRT060128, a Novel Intravenous and Oral P2Y12 Inhibitor, in Non-Urgent PCI

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a multi-center, randomized, double-blind, triple-dummy, clopidogrel-controlled study of IV and oral PRT060128 compared to clopidogrel in patients undergoing non-urgent (including elective) PCI. After diagnostic angiography, patients scheduled for non-urgent PCI will be randomized to clopidogrel or to one of three dose levels of PRT060128.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Portola Pharmaceuticals
• Treatments: Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• The patient is scheduled to undergo non-urgent PCI

• The patient is between 18 and 75 years of age (inclusive) and willing to comply with the protocol

• Women of childbearing potential must have a negative serum or urine pregnancy test within 24 hours of dosing. All patients must agree to use double barrier contraception during the study and for at least 4 weeks after their last dose.

• The patient or legally acceptable representative is able to read and give written informed consent and has signed an informed consent form approved by the Investigator's IRB/IEC

Exclusion Criteria:

• Estimated or measured weight < 55 kg

• Acute non-ST-segment elevation myocardial infarction (NSTEMI) or ST-segment elevation myocardial infarction (STEMI) within 7 days prior to PCI

• Chronic total occlusion or unprotected left main stenting

• Cardiogenic shock (systolic blood pressure < 90 mm Hg requiring vasopressor or hemodynamic support)

• Uncontrolled hypertension at the time of initial study drug administration defined as measured systolic blood pressure > 190 mm Hg or diastolic blood pressure > 108 mm Hg

• Planned staged PCI

• Planned surgery during the study period

• Planned GP IIb/IIIa use

• Patient has received a clopidogrel loading dose (≥300 mg) within 7 days prior to randomization; patients on maintenance clopidogrel may be enrolled

• The planned administration of the study-specified clopidogrel loading dose is >12 hours prior to PCI

• Administration of thrombolytic agents, fondaparinux, or oral anticoagulants (e.g., warfarin) within the 7 days prior to PCI

• Estimated creatinine clearance (e.g. Cockcroft-Gault) < 45 mL/min

• Anemia with hemoglobin level < 10 g/dL

• Thrombocytopenia (platelet count < 100,000/mm3)

• ALT and/or AST > 2.5 x the ULN or other indication of clinically significant hepatic dysfunction

• Facial or head trauma within the last 30 days

• Intraocular hemorrhage within the last 30 days

• Gastrointestinal bleeding within the last 30 days

• Active bleeding, or history of a bleeding disorder or known intracranial vascular malformation

• History of any prior ischemic stroke or TIA within the last 5 years or intracranial hemorrhage, neoplasm, or arteriovenous malformation

• Known allergy or contraindication to the components of PRT060128, aspirin, heparin, clopidogrel, glycoprotein IIb/IIIa inhibitors, or to any contrast media

• Participation in any investigational drug study within 30 days prior to enrollment. Participation in a device trial prior to enrollment is acceptable

• Prior participation in any study involving PRT060128

• Any condition which could interfere with, or the treatment for which might interfere with, the conduct of the study or which would, in the opinion of the Investigator, unacceptably increase the patient's risk by participating in the study. This would include, but is not limited to alcoholism, drug dependency or abuse, psychiatric disease, epilepsy or any unexplained blackouts