A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthetic Hypericin in HIV-Infected Subjects

• Status: Completed
• Trial end date: 1995-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the safety and tolerance of daily oral hypericin when given to achieve target trough levels within defined cohorts. To determine the responses of surrogate markers of HIV infection to daily oral hypericin.

It is not known whether daily oral dosing will produce a tolerable prolonged exposure to therapeutic levels of hypericin. Pharmacokinetic modeling studies have demonstrated that daily oral dosing should produce a trough level in a desired range without excessive peak levels.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Collaborator: VIMRx Pharmaceuticals
• Treatments: Hypericin

Criteria

Inclusion Criteria

Concurrent Medication:

Required:

• PCP prophylaxis.

Allowed:

• Rifabutin, ketoconazole, fluconazole, and acyclovir, provided the medication has been taken for at least 4 weeks prior to study entry without toxicity.

• Topical medications such as clotrimazole troches or nystatin suspension.

Patients must have:

• Documented HIV infection.

• CD4 count <= 350 cells/mm3.

• p24 antigen positive at >= 35 pcg/ml.

• No active opportunistic infection at study entry that would require curative or suppressive therapy.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Malignancy for which systemic chemotherapy is required.

• Medically significant liver disease, orthostatic hypotension, hypertension, cardiac disease, seizure disorders, or lymphoma.

• Any medical condition that would interfere with evaluation of the patient.

Concurrent Medication:

Excluded:

• AZT, ddI, ddC, d4T, or any other antiretroviral medication.

• Interferon or other immunomodulating drugs.

• Cytotoxic chemotherapy.

• Foscarnet.

• Ganciclovir.

• Antimycobacterial drugs other than rifabutin.

• MAO inhibitors.

• Hypertension-inducing, nephrotoxic, or hepatotoxic drugs.

• Opiates.

• Drugs known to cause photosensitivity.

Prior Medication:

Excluded within 1 month prior to study entry:

• AZT, ddI, ddC, d4T, or any other antiretroviral medication.

• Interferon or other immunomodulating drugs.

• Cytotoxic chemotherapy.

• Preparations known to contain hypericin.

Excluded within 3 months prior to study entry:

• Ribavirin.

• Hyperforate (500 mg tablets or ampules for IV injection) manufactured by Kline.

• Psychotonin M Alcohol Extract manufactured by Steigerwald.

• Hypericin (40 mg vial) by VIMRx.

Excluded within 14 days prior to study entry:

• Foscarnet.

• Ganciclovir.

• Antimycobacterial drugs other than rifabutin.

• MAO inhibitors.

• Hypertension-inducing, nephrotoxic, or hepatotoxic drugs.