A Pharmacokinetics, Pharmacodynamics and Safety Study of Warfarin in Combination With Tamiflu (Oseltamivir)
Status:
Completed
Trial end date:
2008-07-01
Target enrollment:
Participant gender:
Summary
This is an open-label, randomized, 2-period crossover study, to evaluate the
pharmacokinetics, pharmacodynamics, safety and tolerability of warfarin in combination with
Tamiflu (oseltamivir) in participants stabilized on warfarin. Participants will be randomized
to receive either their warfarin followed oseltamivir and warfarin, or by oseltamivir and
warfarin followed by warfarin. The treatment periods will be separated by a washout period of
at least 4 days. Participants will continue receiving warfarin once daily at a prescribed
usual dose throughout the study.