A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism

• Status: Completed
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Studies of myocardial fuel selection using a novel palmitate-based PET probe

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Lean:

• BMI<25 kg/m2

• normal glucose tolerance by 75g oral glucose tolerance test

• Type 2 diabetes mellitus:

• BMI >25 kg/m2

• previously diagnosed type 2 diabetes mellitus

• on oral and/or injected insulin treatment.

Exclusion Criteria:

• Lean:

*Use of any chronic medications

• Type 2 diabetes mellitus

• known microvascular disease

• known coronary or other macro vascular disease

• use of PPARgamma class antidiabetic agents within 6 months