A Novel Immunotherapy PD-1 Antiboty to Suppress Recurrence of HCC Combined With PVTT After Hepatic Resection

• Status: Unknown status
• Trial end date: 2020-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Hepatic resection is the most effective curative treatment for resectable HCC, whereas frequent recurrence usually impaired the efficacy of hepatic resection and contributed poor survivals. PVTT has been certified as an independent risk of early recurrence.

Although TACE has been used to decrease the intraheptic recurrence. However, the intraheptic recurrence rate remains high and meanwhile it is uncapable to suppress extrahepatic recurrence. In addition, systematic therapy the small molecular target antiangiogenesis medicine sorafenib were used to prevent recurrence. Unfortunately, the STORM trial shows that postoperative antiangiogenesis therapy was failed to suppress recurrence and prolong survival period for HCC patients. Thus, novel effective systematic therapy to suppress postoperative recurrence is in urgent need.

At present, the PD-1 antibody has presented a promising and safe therapeutic result of unresectable HCC and provided good survival benefit for advanced HCC patients. Consistent with this, we proposed a hypothesis that a novel immunetherapy using the PD-1 antibody could suppress postoperative recurrence and prolong HCC patients survival period effectively.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cancer Hospital of Guangxi Medical University
• Treatments: Antibodies; Immunoglobulins

Criteria

Inclusion Criteria:

• HCC comfirmed by postoperative histology examination

• PVTT comfirmed by postoperative histology examination

• None other type of malignant tumors

• None intra or extra-hepatic recurrence postoperative adjuvant therapy

• Child-pugh grade A or B liver function

• None other organ dysfunction

Exclusion Criteria:

• Combined with other type of malignant tumors

• Presence of intra or extra-hepatic recurrence

• Child-pugh grade C liver function

• Combined with other organ dysfunction