A Novel Approach to Endometrial Preparation in Recipients of Donor Eggs

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

This study compares two different methods to prepare the uterine lining of recipients for implantation in cycles using donor eggs. The study method requires less time than the standard method.

It is hypothesized that both methods would be suitable for use in egg donor cycles.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kelly, Maureen, M.D.
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Ganirelix; Leuprolide

Criteria

Inclusion Criteria:

• recipients awaiting egg donation

• some ovarian function

• normal endometrial cavity

Exclusion Criteria:

• submucosal myoma

• myoma(s) greater than 4 centimeters

• endometrial polyp

• DES exposure

• documented recalcitrant thin endometrium ( <7 mm)

• untreated vulvovaginitis

• active pelvic infection

• endometrial cancer or suspected/known hormonally sensitive cancers

• breast cancer

• thromboembolic disease

• cerebrovascular or coronary heart disease

• diabetes mellitus

• hepatic tumors or active liver disease

• severe hypertension

• headaches with neurologic disease

• cholestatic disease

• heavy smoking over age 35