A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning
Status:
Not yet recruiting
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
The overall aim of this project is to implement a non-invasive method of measuring
quantitative regional cerebral blood flow (rCBF) on the UAB hybrid PET/MRI scanner to allow
conducting such [O-15]water based scans with relative ease and safety in a large variety of
important clinical and research applications. Participants will undergo imaging at baseline
and after administration of a drug to increase cerebral blood flow to evaluate perfusion
estimates during low and high flow states. The goal of this study is to generate data that
will justify eliminating invasive arterial sampling in most [O-15]water-based PET protocols.